Cian Reid has just submitted his PhD on profiling the immune response to a range of bacterial and viral PAMPs over the course of the animal's life. This project will help identify disease-associated immunophenotypes in cattle.
Dr Elaine Waters
Elaine was funded by an SFI Industry Fellowship to investigate the efficacy of bovine Defensin peptides against Mycoplasma bovis.
Elaine was funded by an SFI Industry Fellowship to investigate the efficacy of bovine Defensin peptides against Mycoplasma bovis.
Sarah Swoboda
Sarah developed a nasal epithelial cell culture model to assess the role of B-defensin host defence peptides in protecting calves against viruses. By inducing these protective genes we may be able to boost innate immunity.
Sarah developed a nasal epithelial cell culture model to assess the role of B-defensin host defence peptides in protecting calves against viruses. By inducing these protective genes we may be able to boost innate immunity.
Dr Sajab Bhat investigated the epigenetic mechanisms contributing to disease susceptibility and pathogenesis of TB.
Susana Flores
Susana characterised the role of fat-soluble vitamins, particularly Vitamin D, in the activation and function of neutrophils in response to mycobacteria - the cause of bovine tuberculosis.
Susana characterised the role of fat-soluble vitamins, particularly Vitamin D, in the activation and function of neutrophils in response to mycobacteria - the cause of bovine tuberculosis.
Dr Eimear Donnellan
Eimear characterised differences in immune activation in the female reproductive tract by sperm which contributed to differences in pregnancy rate using high and low fertility bulls.
Eimear characterised differences in immune activation in the female reproductive tract by sperm which contributed to differences in pregnancy rate using high and low fertility bulls.
Dr Laura Parreno
Laura worked on identifying differences in cervical immune function may contribute to breed-specific differences in sheep reproductive success.
Laura worked on identifying differences in cervical immune function may contribute to breed-specific differences in sheep reproductive success.
Dr Megan O' Brien
Megan's project focused on the functional characterisation of the Interleukin 8 gene in cattle. We have discovered two versions of this gene in Holstein-Friesians and this work will help us understand how the different versions contribute to the innate immune response in calves.
Megan's project focused on the functional characterisation of the Interleukin 8 gene in cattle. We have discovered two versions of this gene in Holstein-Friesians and this work will help us understand how the different versions contribute to the innate immune response in calves.
Dr Sanjay Mallikarjunappa
Sanjay has focused on the identification of genes associated with resistance to infection with Mycobacterium avium subsp. paratuberculosis - the casuative agent of Johne's disease in cattle.
Sanjay has focused on the identification of genes associated with resistance to infection with Mycobacterium avium subsp. paratuberculosis - the casuative agent of Johne's disease in cattle.
Dr Nicholas Ryan
The focus of Nick's PhD was the evaluation of the prevalence and impact of post-partum endometritis on cows under a pasture-based system of dairying. The second part of his PhD centres on the identification of optimal biomarkers for disease diagnosis.
The focus of Nick's PhD was the evaluation of the prevalence and impact of post-partum endometritis on cows under a pasture-based system of dairying. The second part of his PhD centres on the identification of optimal biomarkers for disease diagnosis.
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Dr Charlotte Beynon
Charlotte started a project which is developing assays for immunophenotyping in cattle. |
Dr Amy Brewer
Amy took up the torch from Cathriona Foley and performed a large next-generation sequencing project to identify the gene expression changes in endometrial epithelial cells that precede the development of clinical and subclinical endometritis.
Amy took up the torch from Cathriona Foley and performed a large next-generation sequencing project to identify the gene expression changes in endometrial epithelial cells that precede the development of clinical and subclinical endometritis.
Dr Paul Kelly
Paul performed his PhD on characterisation of the molecular signalling pathways behind the activaton of IL-1B. IL-1B is a potent inflammatory signal that plays a role in most infectious diseases.
Paul performed his PhD on characterisation of the molecular signalling pathways behind the activaton of IL-1B. IL-1B is a potent inflammatory signal that plays a role in most infectious diseases.
Dr Ronan Whiston
Ronan worked with Emma, and his bioinformatics skills contributed to the same work as well as performing a whole-exome sequencing project in bulls of high and low fertility. This identified a panel of novel SNPs which are also associated with bull fertility.
Ronan worked with Emma, and his bioinformatics skills contributed to the same work as well as performing a whole-exome sequencing project in bulls of high and low fertility. This identified a panel of novel SNPs which are also associated with bull fertility.
Dr Emma Finlay
Emma brought valuable bioinformatics expertise to our group (as a postdoc) and performed a number of analyses which resulted in the detection of a novel association between B-defensin haplotype and bull fertility.
Emma brought valuable bioinformatics expertise to our group (as a postdoc) and performed a number of analyses which resulted in the detection of a novel association between B-defensin haplotype and bull fertility.
Dr Anne-Barry Reidy
Anne worked on the identification of stimuli that drive defensin expression, with a focus on the female reproductive tract. Anne also did some nice bioinformatics to identify conserved regulatory elements across defensins, between species that will hopefully help identify transcription factors that control expression of these important genes.
Anne worked on the identification of stimuli that drive defensin expression, with a focus on the female reproductive tract. Anne also did some nice bioinformatics to identify conserved regulatory elements across defensins, between species that will hopefully help identify transcription factors that control expression of these important genes.
Dr Tamsin Lyons
Tamsin worked on the interface between microbiology and immunology by characterising the host-microbe interactions during the initial colonisation of the intestine in calves.
Tamsin worked on the interface between microbiology and immunology by characterising the host-microbe interactions during the initial colonisation of the intestine in calves.
Dr Ciaran Harte
Ciaran began our work optimising novel adjuvants to enhance innate immunity in calves. His work formed the basis for follow on applications and a potential route to improve vaccination in cattle.
Ciaran began our work optimising novel adjuvants to enhance innate immunity in calves. His work formed the basis for follow on applications and a potential route to improve vaccination in cattle.
Dr Bojan Stojkovic
Bojan started the ball rolling on the characterisation of the Interleukin 8 haplotypes we discovered. His in vivo model of responses to LPS in calves showed how both haplotypes drive significantly different IL8 expression profiles.
Bojan started the ball rolling on the characterisation of the Interleukin 8 haplotypes we discovered. His in vivo model of responses to LPS in calves showed how both haplotypes drive significantly different IL8 expression profiles.
Dr Cathriona Foley
Cathriona did her PhD on endometritis in dairy cows and her next-generation sequencing approach gave us some valuable new insights into the immune changes preceding disease development.
Cathriona did her PhD on endometritis in dairy cows and her next-generation sequencing approach gave us some valuable new insights into the immune changes preceding disease development.